Concentration Gradients

Concentration Gradients

Critically, the SciFlow system allows the user to generate in vivo like non-linear exposure models in vitro. Non-linear concentration gradients are critical descriptors in many in vivo processes. For example, SciFlow has the potential to recapitulate the pharmacokinetics of an injected or ingested drug in vivo where the concentration of a drug is constantly changing due to principles of absorption, distribution, metabolism, and excretion (ADME). This attribute of the SciFlow system could vastly improve in vitro to in vivo extrapolation (IVIVE) affording better prediction of ultimate clinical outcomes. Enhanced predictivity and more relevant IVIVE conclusions are precisely the data sets desired by numerous industries.